How to Work With Your tellmeGen Raw Data
A practical pipeline for turning a tellmeGen raw data export into a build-verified VCF, running quality control, annotating it, and understanding what a genotyping array can and cannot tell you.
Tag: vcf
6 posts
You Found Your FoundMyFitness Genetic Report. Here's What It Can and Can't Tell You
A FoundMyFitness report is a literature annotation layer on top of a consumer genotyping array. Here's how to audit the underlying file, rebuild the analysis yourself, and understand where array data runs out.
How to Analyze Your Raw DNA Data Without a Paid Upload Site
A working guide to the free DNA upload sites worth using, what each one does with your file, and how to run the same annotation, polygenic scoring, and relative-matching analyses yourself on your own machine.
How to Check Your Own MTHFR Genotype from Raw DNA Data
A step-by-step method for pulling rs1801133 and rs1801131 out of a 23andMe, AncestryDNA, or WGS file yourself, getting the strand right, and understanding what the result does and does not tell you.
How to Read Your Raw DNA Data Yourself
A working guide to interpreting raw genotype files from 23andMe or Ancestry, converting them to VCF, annotating variants, and knowing where array data stops being useful.
How to Analyze Your Raw DNA Data
A working guide to taking a 23andMe/Ancestry export or a whole-genome FASTQ, converting it to an annotated VCF, filtering it sensibly, and knowing which results are real.